I'm experimenting with the text adventure version of Quest minus a command bar. Is there a way achieve all of the following together?

1. After selecting "speak to" for a given character, have a list of questions appear as in a verb display/drop down menu.
2. Introduce, get rid of, change the set of questions depending on the story situation.
3. Not have the "1:Yes 2:No" confirmation appear, but instead go straight to the character's answer.

No worries if it can't be done. I'm just curious.

Short answer... yes...
Check out the documentation: http://docs.textadventures.co.uk/quest/
And this: http://docs.textadventures.co.uk/quest/conversations.html

you need to learn about menus, looping, and List/Dictionary Attributes:

http://docs.textadventures.co.uk/quest/scripts/show_menu.html // 'show menu' is a popup window menu
http://docs.textadventures.co.uk/quest/functions/showmenu.html // 'ShowMenu' is a hypertext menu

(you can create your own custom menu display as well, ask/let-me-know if you want to do this)

http://docs.textadventures.co.uk/quest/scripts/if.html
http://docs.textadventures.co.uk/quest/scripts/switch.html

http://docs.textadventures.co.uk/quest/using_lists.html
http://docs.textadventures.co.uk/quest/using_dictionaries.html

http://textadventures.co.uk/forum/samples/topic/5137/list-and-dictionary-extensive-guide-by-hk (my own guide on using lists/dictionaries)

http://docs.textadventures.co.uk/quest/display_verbs.html // (while this is on the built-in 'displayverbs/inventoryverbs' Stringlist Attributes, which control the displayment/usage of your Object's Verbs in the side panels as buttons and as hyperlinks in the big text box on the left, it also teaches you about adding/removing items from any list/dictionary in generally)

http://docs.textadventures.co.uk/quest/scripts/foreach.html
http://docs.textadventures.co.uk/quest/scripts/for.html

http://docs.textadventures.co.uk/quest/scripts/while.html

(you can, and should --- as the 'while' Script/Function has some issues, also easily create your own looping scripts/functions, ask if you need help on how to do them)

http://docs.textadventures.co.uk/quest/character_creation.html (this is a great starting place to learn about menu and list usage)

Absolutely:

1. Yes! When you select Speak To, have it run a Script that makes a StringList variable, which you then populate with various Strings. Then show a Menu for that list, and after the player selects, have a Switch depending on 'result'.

2. Yes! That StringList I mentioned earlier? Have ANOTHER Stringlist filled with potential options. So you do basically 'For each String in ListOfOptions, add String to MenuStringList'. And you can add or remove from ListOfOptions - just an example name, name it whatever you want - as you want!

3. Yes! As earlier, the Menu avoids this entirely.

ABSOLUTELY learn how Menus work. In my opinion, they are among the most powerful tools Quest has to offer.

the current version of Quest, should have (I believe/assume) Pixie's advanced conversation/dialogue/topic system built into it, doing everything that you want, but you got to learn how to use it of course

the built-in 'ask/Ask' Scripts/Functions are a bit misleading in how they work, which a lot of new people don't realize:

('ask' does a popup window menu and 'Ask' does a hypertext menu)

http://docs.textadventures.co.uk/quest/scripts/ask.html

as it's actually a 'yes:true/no:false' lawyer/court answering system (you can't use 'ask/Ask' for doing normal types of questions and answers, as 'ask/Ask' only allow for yes/no type of questions/answers)

for example:

<function name="example_function">
  msg ("Your Name?")
  get input {
    player.alias = result
    string_variable = "Is, " + player.alias + ", correct, as the name that you want for yourself?"
    ask (string_variable) {
      // if you chose, yes: result = true
      // if you chose, no: result = false
      if (result) { // if (result = true) 
        msg ("Your name is: " + player.alias)
      } else { // if (result = false)
        ClearScreen
        example_function
      }
    }
  }
</function>

If you are using the desktop version, this library will do it all for you:
https://github.com/ThePix/quest/wiki/Library:-Conversations

Thank you everyone for your tremendous help (sometimes I struggle to follow the documentation explanations by themselves). Now I have lots ideas and options to build upon.