The idea is the game will have a prestige store that currency is earned for through each life which you die in and save the results. This unlocks various options from skills to consumables, to realms(From which current locations, enemies, skills, perks, artifacts, etc come from) Is this the best choice of an engine for me to use for such a game?

It can be done.

That's cool.
A few people have created games like that on here. Me, The Pixie, and at least one other guy. You can always find the code using a search engine.